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Improvement in skin hydration and luminosity after just 2 sessions
0%
Increase in skin firmness and elasticity in treated areas
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of clients reported visibly healthier, more radiant skin following a full course

Profhilo is a groundbreaking, premium and chemical-free, bio-remodelling injectable composed of ultra‑pure high‑ and low‑molecular‑weight hyaluronic acid (64 mg in 2 ml) formulated using patented NAHYCO® hybrid technology. This is not a filler, it delivers intense hydration while stimulating four types of collagen and elastin to remodel skin structure and firmness from within - for a naturally lifted, radiant complexion without added volume.

Profhilo is BBDE-free, this means that the product does not contain BDDE (1,4-Butanediol diglycidyl ether), which is a chemical compound commonly used to cross-link hyaluronic acid in traditional dermal fillers. Cross-linking makes the HA gel last longer in the skin, but it also involves adding synthetic stabilisers like BDDE – which, while generally considered safe in low levels, can potentially cause irritation, inflammation, or long-term sensitivity in some individuals.

So when a product like Profhilo is BDDE-free, it means:

  • It contains no chemical cross-linking agents, only ultra-pure hyaluronic acid.

  • It’s biocompatible, with minimal risk of inflammatory response.

  • The skin can fully absorb and utilise it for natural hydration and stimulation of collagen and elastin.

This is one of the reasons Profhilo is often called a “bioremodelling treatment” rather than a filler — it improves skin quality from within without changing facial volume or structure.

Ideal for treating:

  • Skin laxity and early signs of facial sagging

  • Fine lines, dehydration, dullness

  • Crepey texture or thinning skin on face, neck, décolleté, hands
    It’s perfect for both prevention (30s upwards) and rejuvenation in mature skin.

Once the numbing cream has activated, the treatment takes place in approximately 15 minutes using the Bio Aesthetic Point (BAP) technique: just 5 micro‑injections per side of the face to maximise diffusion and minimise bruising. This ensures even spread of the hybrid Hyaluronic Acid throughout facial tissues.

  • Two treatments, one month apart, are standard.

  • Many clients notice improved hydration, glow and subtle softening within 10-14 days of the first session.

  • The full bioremodeling effects-enhanced firmness, elasticity, texture-typically emerge several weeks after the second session as collagen and elastin rebuild.

  • Effects generally last 6-9 months, depending on individual skin condition and lifestyle.

  • For long-term benefit, a single-touch maintenance session every 6-9 months is recommended.

Profhilo is very well tolerated-using pure HA without cross‑linking agents reduces inflammation and risk of reactions. Side‑effects, are minimal: mild swelling or temporary bumps that usually resolve within 48 hour, or ocassioanly, slight brusing at the injection site. Clients can resume daily activities immediately.

Yes. Profhilo integrates flawlessly with surface and structural treatments. It pairs exceptionally well with the ‘Facial reset’ and targeted therapies like Polynucleotides or blemish removal, delivering multi‑layered rejuvenation. Customised facial packages blending Profhilo with CACI Synergy or advanced skincare can be designed following consultation.

Saskia offers clinic-grade injectable protocols in a luxury mobile setting, bringing advanced bioremodelling expertise directly to you. Every treatment is individually planned to suit your facial structure and skin condition, with careful selection of injection points and tailored protocols for optimal results.

Aspiration is performed at every injection point to ensure maximum safety, and a full sterile mobile setup is used for every visit, maintaining clinical standards of hygiene and care regardless of your location. This dedication to precision, cleanliness, and results makes Saskia London the ideal choice for clients seeking a professional, discreet, and high-performing Profhilo experience.

Profhilo Technology Comparison

Feature Plinest (Polynucleotides) Seventy Hyal 200 Profhilo
Main Function Cellular regeneration, tissue repair, anti-inflammatory Hydration, glow, skin texture Hydration, firmness, collagen stimulation
Mechanism Stimulates fibroblast growth, DNA repair, collagen & elastin production Replenishes HA in dermis, supports hydration and elasticity Stimulates 4 types of collagen + elastin via slow-release HA
First Visible Results 7–10 days 2-3 days 5–7 days
Peak Results 3–4 weeks 2–3 weeks 4 weeks
Course Required 3–4 sessions, 2–3 weeks apart 2–3 sessions, 2–4 weeks apart 2 sessions, 4 weeks apart
Maintenance Every 4–6 months Every 3–6 months Every 6 months
Best For Thin, damaged, inflamed, or mature skin; post-acne scarring; dullness Hydration, mild plumping, glow Laxity, fine lines, dullness, crepey skin
Why Saskia London chose it Backed by published clinical studies in the Journal of Dermatological Science, Plinest has been shown to increase fibroblast proliferation by over 60%, making it one of the most effective bioregenerative injectables for restoring skin damaged by age, acne, or inflammation. It’s unmatched in its ability to repair at a cellular DNA level. Seventy Hyal 200 delivers 200mg/ml of bio-stimulating hyaluronic acid with ultra-low molecular weight—allowing for deeper dermal absorption and up to 45% improvement in hydration in just 48 hours, as demonstrated in European multicentre trials. Its glow-boosting effect is ideal for younger clients or those new to injectables. Profhilo contains the highest concentration of pure HA available (64mg/2ml) and is the only injectable clinically proven to stimulate Types I, III, IV, and VII collagen, with studies in Clinical, Cosmetic and Investigational Dermatology showing firmness and elasticity improvements of over 30% after two treatments. It’s the gold-standard skin remodeler worldwide.